At this site you can download the isimatch software which is described in `Semi-automatic construction of reference standards for evaluation of image registration', K. Murphy, B. van Ginneken, S. Klein, M. Staring, B.J. de Hoop, M. A.Viergever and J. P. W. Pluim.
Medical Image Analysis 15 pp 71-84 2011
Please cite this article if you use the software in any publications.

This software was originally designed for private use, so if you have any problems using it please contact me at keelin@isi.uu.nl. Instructions to download the software and user guides are below.

Please click HERE to download the file ix.zip which contains the isimatch software. When you download the software you will have a bin directory which contains everything you need. There are two major components to the system: A document to be used as a guide for observers who will be end users of the system is available HERE (Most of this information is already contained in the guide for the MPA component, but this is a more basic set of instructions with screenshots etc. for the end user) If you have any difficulties with installation, useage, setting parameters etc. please feel free to contact me at keelin@isi.uu.nl .